Innovative SPECTROSCOPY

JOBIN YVON is based on one of the worldwide eldest optical companies, founded for the production of optical components to determine the quality of the light and its interaction with the material. For all that ideas of prominent pioneers in optics like e.g. FRESNEL, ARAGO, REGNAULT, BABINET have been realized. In 1893 AMÉDÉÉ JOBIN bought the company and gave it to his son-in-law GUSTAVE YVON, who leaded it until 1961 under the name JOBIN YVON.

Since 1974 JOBIN YVON is part of the internationally known holding INSTRUMENTS S.A. for production of systems for the research with subsidiaries in Germany, England, Italy, the Netherlands and the USA. During the next years the companies SPEX, DILOR und SOFIE came to this holding, all well-known by spectroscopic researchers.

1997 INSTRUMENTS S.A. becomes part of the world wide operating Japanese holding HORIBA, and covers today with its products nearly all parts of the optical spectroscopy.

• Raman Spectroscopy
• Optical Spectroscopic Systems
• Fluorescence Spectroscopy
• Optical Gratings, CCD-Detectors and OEM-Components for System producers
• Ellipsometry and Thin Film Process Control
• Emission Spectroscopy
• VUV Instrumentation
• Forensic Imaging and Spectroscopic Systems
• Micro X-Ray Fluorescence

The company JOBIN YVON GMBH is the European exclusive representation of the short pulse lasers by Clark-MXR.

Clark-MXR, Inc. is one of the leading producers of Femto- and Picosecond Amplifier systems for research and industrial applications. Since the invention of the CPA-Technology ("Chirped Pulse Amplification") in 1985 Clark-MXR consequently made further developments in this technology and Clark-MXR is one of the driving forces in optimising these systems. The market introduction of the CPA-200x Series, the first compact and integrated amplifier systems in 1997 was one of the milestones in this development and underscores the prime role of Clark-MXR. As an example, diodes with a lifetime of up to 20 years are used for as pump diodes in the CPA-200X systems. The outstanding ease-of-use leads to new applications. Further product lines for the Femtosecond field like frequency converting systems, pulse analysing systems, pulse modifying systems etc. round up the product range.

Jobin Yvon GmbH
Neuhofstr. 9
64625 Bensheim
Tel: 06251 / 8475-0
www.jobinyvon.de


HECUS X-RAY SYSTEMS GMBH

Hecus M.Braun is a leading developer and supplier of instrumentation for X-ray scattering. The product line includes industrial-standard camera systems for simultaneous small- and wide-angle X-ray scattering, both for nanostructural phase property mapping / high-throuput screening in the R&D laboratory, and for on-line, continuous process control in chemical production. Customer support includes special training courses and expert advice with particular applications, ranging from powders to soft condensed matter, and to macromolecular solutions.

HECUS X-RAY SYSTEMS GMBH
Moserhofgasse 15a
A-8010 GRAZ, AUSTRIA
43 316 481118-0 tel
43 316 481118-20 fax
e-mail: office@hecus.at
URL: http://www.hecus.at

Booth Personnel:
Hermine Fermin
Peter Laggner


Bruker AXS, Inc.

Bruker AXS produces advanced materials characterization tools using x-ray technology. Typical applications range from pharmaceutical powders to catalysts and other new or traditional materials. At IWPCPS-5 Bruker will feature the D8 CST, a high throughput screening system for combinatorial transmission applications.


TSI GmbH

TSI GmbH of Aachen, Germany, is a corporate sales and service offices of TSI Incorporated located in St. Paul, Minnesota (USA). TSI Incorporated has about 800 employees world-wide. TSI designs and manufactures a variety of particle instruments.

Our Powder Instruments line includes products for dry solid particle size analysis, powder flowability analysis, and chemical composition analysis. These unique instruments have an emphasis on high-resolution quantitative results and simple operation. Multiparameter instruments provide information covering size, shape, charge and composition of particles and powder flowability. For modern physical characterization of pharmaceutical solids, particularly in the areas of drug discovery, formulation, and quality control we offer:

* Model 3603 Particle Size Distribution Analyzer (PSD) The PSD 3603 is a powerful, single-particle-counting analyzer for characterizing pharmaceutical powders and medical aerosols according to particle size. It measures dry, unprepared powders in the range from 0.3 to 500 micrometers in diameter using an aerodynamic time-of-flight technique. Key features include software with raw-data security that is useful in obtaining compliance with 21 CFR, Part 11; high-resolution measurements; fast setup and cycle time; complete dispersion without milling; and repeatable results. This powerful instrument provides fast, reliable measurements using a very small sample size. Multiple tests are possible, even when sample quantities are limited. A robust, easy-to-use analyzer, the PSD 3603 is designed and built to meet the rigorous demands of pharmaceutical manufacturers.

* Model 3250 Aero-Flow™ Powder Flowability Analyzer The Aero-Flow™ powder flowability analyzer removes the uncertainties associated with measurement of the most commonly observed but never well characterized properties of powders, that of powder cohesion. This completely automated instruments does away with the traditional and subjective "slump-test" providing the industry with an objective, quantitative measure of powder flowability and cohesivity.

* Model 3980 Gas-Phase Electrophoretic-Mobility Macromolecule Analyzer (GEMMA) The GEMMA method is a powerful new tool for high-speed size analysis of macromolecules. GEMMA offers proven utility in a variety of biological and pharmaceutical applications. The list includes characterization of proteins, glycoproteins, protein aggregates, protein-protein interaction products, high-mass noncovalent protein complexes, whole viruses, whole cell organelles, micelles, drug vehicles, break-down products of macromolecules (consistency analysis), and nanoparticles of biological importance. Interchangeable columns allow coverage of an extremely wide dynamic size range, from approximately 8 kDa (monomer of insulin) to over 100 MDa (whole-cell organelles and some viruses). In addition to providing size analysis of macromolecules, GEMMA is also capable of passing a constituent macromolecule of the distribution to other applications by means of a continuous flow.

TSI GmbH
Particle Instruments
Neuköllner Str. 4
D-52068 Aachen
Germany
Tel.:0(049)241-5 23 03 0
Fax: 0(049)241-5 23 03 49
Email:Particle-Europe@tsi.com
Internet: http://powder.tsi.com


Raman Spectroscopy

Kaiser Optical Systems, Inc., a Rockwell Collins Company, is a world leader in the production of high-performance holographic optical elements (HOEs) for spectroscopic, aerospace, and military applications. Our holographic notch filters for laser line rejection have revolutionized Raman spectroscopy. Our innovative fiber optic probe, imaging spectrograph, and transmission grating technologies provide a solid foundation for a complete family of compact, high-performance, extremely reliable instrumentation: the RamanRxn Systems™ family of Raman analyzers.

RamanRxn Systems analyzers are at work wherever analyses need to be fast and non-invasive. RamanRxn1™ analyzers are in the R&D lab probing the behaviors of enzymes, exploring the structures of new materials with microscopy, and screening drug candidates with HTS. RamanRxn2™ and RamanRxn3™ process analyzers are in the process line monitoring reactions, polymerizations, and polymorph transformations-all in situ. And they're at the process line analyzing moving polymeric films and fibers, semiconductors, and DLC films with non-contact optics.

To learn more about our company and our products, visit www.kosi.com

Europe
Kaiser Optical Systems, SARL
5 Allée du Moulin Berger
69130 Ecully, France
Phone: +33 (0)4-37-49-90-73
Fax: +33 (0)4-37-49-91-03
E-mail: europe@kosi.com

USA & International
Kaiser Optical Systems, Inc.
371 Parkland Plaza
Ann Arbor MI 48103 USA
Phone: +1 734-665-8083
Fax: +1 734-665-8199
E-mail: sales@kosi.com


STOE & Cie GmbH

In Darmstadt, Germany, STOE & Cie GmbH developes and manufactures powder and single crystal diffractometer systems as well as control and evaluation software for crystallographers, solid state chemists and pharmacists all over the world. Especially for the pharmaceutic industry STOE launched in 2001 the STADI P COMBI, a powder diffractometer for combinatorial and high-throughput analysis of up to 96 samples in transmission mode. The STADI P COMBI will be presented at the exhibition.

STOE & Cie GmbH
Hilpertstr. 10
D-64295 Darmstadt
Germany

Tel: +49 6151 9887-0
Fax: +49 6151 988788
e-mail: stoe@stoe.com
hompage: www.stoe.com


Sympatec GmbH

Sympatec GmbH, System-Partikel-Technik
Head Office:	Clausthal, Technologiezentrum Burgstätter Str. 6, D-38678 Clausthal-Zellerfeld Tel.: +49 5323 717-0, Fax: +49 5323 717-229 sales@sympatec.com / www.sympatec.com
Production & Development	D-38644 Goslar, Unternehmenspark, Pracherstieg 1
Sales Offices Germany	Clausthal (Germany central) Hamburg (Germany north + Denmark) Krefeld (Germany west) Leipzig (Germany east, Czech Rep. and Slovakia) Rosenheim (South east + Austria)
Subsidiaries	Basel CH-GmbH, (Germ. south west and Switzerl.) Bury Sympatec Ltd., (United Kingdom and Ireland) Princeton Sympatec Inc., New Jersey, (USA and Canada) Lee Sympatec Inc., Maine, (USA north east) Atlanta Sympatec Inc., Georgia, (USA south east) Fresno Sympatec Inc., Calif., (USA west and Canada) Etten-Leur NL, (Belgium, Netherlands, Luxembourg) Paris France Stockholm Sweden (Nordic countries) Seoul ROK, (South Korea)
Agencies & Distributors	Europe: Finland Greece Hungary Italy Poland Portugal Romania Spain Turkey Overseas: Argentina Brazil Chile China India Indonesia Iran Japan Malaysia Mexico Philippines Singapore South Africa Thailand Vietnam
Field of Activity	Particle Size Analysis
Laser Diffraction	off-, at-, on- and in-line systems for analysis of particle size distributions in modular design.
Sensors	HELOS BF/KF/VARIO: 0.1-8750 µm MYTOS: 0.25 - 3500 µm (on- & in-line) DRYSUBMICRON from 0.1 µm TOPMICRON & MEGAMICRON to 8750 µm Fraunhofer & MIE
Dispersing Systems	off- & at-line dry RODOS & GRADIS * * dry / wet OASIS * * wet QUIXEL & SUCELL * *     CUVETTE * sprays SPRAYER & INHALER *
Sample Couplers	VIBRI (off-, at-, on-line) ASPIROS, ASPIROS-Multi (off-line) TWISTER, INCELL (in-line) ROPRON, SAFIR (on-line)
Software	WINDOX, QX, REMO & PARA,QT, MIE, SPRAY
Ultrasonic Extinction	OPUS & NIMBUS: 0.01 - 3000 µm, CV 70 Vol. %
Photon Cross Correlation Spectroscopy	NANOPHOX: 1 - 10000 nm
Image Analysis	QICPIC: 1 - 10000 µm
Particles	Reference Materials & Validation
Reference	nearly two thousand systems worldwide
Committee Members	DIN/ISO TC24S4 Working committee particle size analysis of VDI.GVC- Gesellschaft Verfahrenstechnik und Chem.ing.wesen

Bruker BioSpin GmbH
Silberstreifen 4
76287 Rheinstetten

Tel: (+49) (721) 5161 - 0
Fax: (+49) (721) 5171 01


Bruker Optik GmbH
NIR & Process Technology Division
Rudolf-Plank-Str. 27
D-76275 Ettlingen
Germany

Bruker Optics offers IR, NIR and Raman spectrometers and related equipment. Our spectrometers, most of them are based on the FT technique, can be used in the laboratory as well as in the warehouse or for at-line, on-line or in-line process analysis in the Pharmaceutical industries. Our validated software, called OPUS, is fully compliant to CFR21part11.





RESULTEC
RESULTEC is a company specialized in Vibrational Spectroscopy and Microscopy.

At the IWPCPS meeting we will present the Illuminat-IR, an FT-IR Spectrometer Module, which can be added to an existing Standard Light Microscope, a Polarization Light Microscope or a Raman Microscope for determining sample composition by Vibrational Spectroscopy. The Illuminat-IR does not compromise existing microscope features but provides additional sample information by chemical analysis using FT-IR.

Another application is the combination of Thermomicroscopy (a polarized light microscope fitted with a hot stage) with Infrared Microspectroscopy for Solid-State Studies of Drug Substances. Different hot stages for various applications will be displayed, ranging from -196 °C up to 600 °C





Hiden Isochema
Our products / services include:

IGAsorp - Moisture sorption analyzer
The IGAsorp and is designed to characterise sorption isotherms, investigate hydrate phases and deliquescence, detect and quantify amorphous phases and measure kinetics such as diffusion rates and Moisture vapor Transmission Rates (MVTR's) using the GVS technique .

IGA - Specialized vapor sorption systems
Our IGA range of instruments can additionally measure the propellant interaction with inhalation products using the vacuum method.

Contract analysis laboratory services
If you require further information please visit our website at www.hidenisochema.com


Setaram Instrumentation
Setaram company supplies standard instruments for every thermal analysis technique, : DTA, DSC, TGA, TMA, TSC, ….in a widest range of devices. Based on different measurements principles, they satisfy both the specific and greatly varying needs of its customers.

Our reputation is built on a solid reputation as expert specialized in high and low temperature thermal analysis and Calvet Calorimetry.

In addition to the products we can provide, we can develop special device to satisfy customers' specific needs.


NOVOCONTROL Technologies
NOVOCONTROL technologies is a German based manufacturer of dielectric spectrometers. Dielectric spectrometers provide an easy access to structure/property relation of solids and liquids used for pharmaceutical products. Dielectric spectra can be presented in 2- and 3- dimensional format and from these molecular dynamics and transport processes in materials can exactly be determined. Typical applications are the determination of physical and chemical properties such as phase transitions, crystallinity, curing, aging, thermal decomposition, blending, purification etc. It can be applied to encapsulation materials, materials for controlled drug release, liposome suspensions, cyclodextrines, polyalcohol, proteins, etc.


PerkinElmer N.V., Belgium



PANalytical
PANalytical is the world's leading supplier of analytical instrumentation and software for X-ray diffraction (XRD) and X-ray fluorescence spectrometry (XRF), with more than half a century of experience. The materials characterization equipment is used for scientific research and development, for industrial process control applications and for semiconductor metrology.

PANalytical, formerly Philips Analytical, employs around 750 people worldwide. Its headquarters are in Almelo, the Netherlands. Fully equipped application laboratories are established in Japan, the USA, and the Netherlands. PANalytical's research activities are based on the campus of the University of Sussex in Brighton (UK). Supply and competence centers are located in Almelo and Eindhoven (NL). A sales and service network in more than 60 countries ensures unrivalled levels of customer support. The company is certified in accordance with ISO 9001:2000 and ISO 14001.

The product portfolio includes a broad range of XRD and XRF systems and software widely used for the analysis and materials characterization of products such as cement, metals and steel, plastics, polymers and petrochemicals, industrial minerals, glass, catalysts, semiconductors, thin films and advanced materials, pharmaceutical solids, recycled materials and environmental samples.

Visit our website at www.panalytical.com for more information about our activities. PANalytical is part of Spectris plc, the precision instrumentation and controls company.


C3-Analysentechnik GmbH / Thermometric AB

C3-Analysentechnik GmbH is the German distributor for calorimeter manufacturer Thermometric AB from Sweden, both companies present the TAM III system- the new generation of the TAM microcalorimeter system.

TAM III is a multichannel microcalorimetric system used to investigate stability, compatibility, amorphicity, polymorphism, binding and many other characteristics of compounds that are important to the pharmaceutical industry. Stability data can be obtained within hours in contrast to many other techniques, which requires accelerated conditions to obtain data within a comparable time frame. TAM III is an ideal tool for compatibility screening at ambient temperatures and humidities without the need to dissolve or in other ways alter the sample prior to analysis. Quantitative and qualitative investigations of amorphicity and crystallinity are of particular interest, much due to the high sensitivity of TAM. TAM III can detect amorphous amounts of less that 1%. A study of the kinetic and energetic relationships between polymorphic forms is yet another application where transition can be monitored in real time at isothermal conditions. TAM III can be used in slow scanning mode (e.g. 2 K h-1) with a temperature resolution that widely exceeds that of conventional DSC. This is of particular interest for studies of glass transitions of amorphous samples as well as phase transitions of polymorphs and hydrates.